Magbagbeola, M;
Doyle, K;
Rai, ZL;
Lindenroth, L;
Dwyer, G;
Stilli, A;
Davidson, BR;
(2022)
Evaluation of A Novel Organ Perfusion Research Platform.
In:
2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC).
(pp. pp. 2565-2568).
IEEE: Glasgow, Scotland, United Kingdom.
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Abstract
This paper presents a novel, low cost, organ perfusion machine designed for use in research. The modular and versatile nature of the system allows for additional sensing equipment to be added or adapted for specific use. Here we introduce the system and present its preliminary evaluation by assessing its ability to maintain a predetermined input pressure. A proportional-integral-derivative (PID) controller was implemented and tested on a porcine liver to maintain input pressure to the hepatic artery and compared to bench tests. The results confirmed the effectiveness of the controller for maintaining input through the hepatic artery (HA) in a timely manner. Clinical Relevance-Machine Perfusion (MP) is proving to be an invaluable adjunct in clinical practice. With its ongoing success in the transplant arena, we propose MP for use in research. A cost-effective, versatile system that can be modified for specific research use to test new pharmacological therapies, imaging techniques or develop simulation training would be beneficial.
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