Verma, V;
Lange, F;
Bainbridge, A;
Harvey-Jones, K;
Robertson, NJ;
Tachtsidis, I;
Mitra, S;
(2022)
Brain temperature monitoring in newborn infants: Current methodologies and prospects.
Frontiers in Pediatrics
, 10
, Article 1008539. 10.3389/fped.2022.1008539.
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Abstract
Brain tissue temperature is a dynamic balance between heat generation from metabolism, passive loss of energy to the environment, and thermoregulatory processes such as perfusion. Perinatal brain injuries, particularly neonatal encephalopathy, and seizures, have a significant impact on the metabolic and haemodynamic state of the developing brain, and thereby likely induce changes in brain temperature. In healthy newborn brains, brain temperature is higher than the core temperature. Magnetic resonance spectroscopy (MRS) has been used as a viable, non-invasive tool to measure temperature in the newborn brain with a reported accuracy of up to 0.2 degrees Celcius and a precision of 0.3 degrees Celcius. This measurement is based on the separation of chemical shifts between the temperature-sensitive water peaks and temperature-insensitive singlet metabolite peaks. MRS thermometry requires transport to an MRI scanner and a lengthy single-point measurement. Optical monitoring, using near infrared spectroscopy (NIRS), offers an alternative which overcomes this limitation in its ability to monitor newborn brain tissue temperature continuously at the cot side in real-time. Near infrared spectroscopy uses linear temperature-dependent changes in water absorption spectra in the near infrared range to estimate the tissue temperature. This review focuses on the currently available methodologies and their viability for accurate measurement, the potential benefits of monitoring newborn brain temperature in the neonatal intensive care unit, and the important challenges that still need to be addressed.
| Type: | Article |
|---|---|
| Title: | Brain temperature monitoring in newborn infants: Current methodologies and prospects |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fped.2022.1008539 |
| Publisher version: | https://doi.org/10.3389/fped.2022.1008539 |
| Language: | English |
| Additional information: | Copyright © 2022 Verma, Lange, Bainbridge, Harvey-Jones, Robertson, Tachtsidis and Mitra. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (http://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | brain temperature, neonatal seizure, neonatal encephalopathy, hypoxic ischaemic encephalopathy, cerebral metabolism, cerebral perfusion, near infrared spectrscopy (NIRS), magnetic resonance spectroscopy (MRS) |
| UCL classification: | UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng UCL > Provost and Vice Provost Offices > UCL BEAMS UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10158043 |
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