Lee, JH;
Park, JH;
Lee, JH;
Lee, HH;
Knowles, JC;
Kim, HW;
(2022)
Matrix-enabled mechanobiological modulation of osteoimmunology.
Matter
, 5
(10)
pp. 3194-3224.
10.1016/j.matt.2022.07.002.
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Abstract
Modulation of osteoimmunology is central to recovering the functions of defective and diseased bone. Here, we highlight the roles of material-enabled matrix in regulating osteoimmunological phenomena such as inflammation, bone hemostasis, and regeneration. We provide an overview of the concept of osteoimmunology and matrix-induced mechanobiology, detail the effort to exploit materials with tunable parameters (ligands, stiffness, viscoelasticity, nano/microtopography, and three-dimensionality) to instruct these events, and discuss the mechanotransduction process and mechanisms underlying the matrix-related interactions between immune/inflammatory cells and bone-forming cells. This will help us to understand matrix-related mechanobiological modulation of osteoimmunology and develop materials with tunable matrix properties for bone healing and regeneration.
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