Brunet, J; Pierrat, B; Adrien, J; Maire, E; Lane, BA; Curt, N; Bravin, A; ... Badel, P; + view all Brunet, J; Pierrat, B; Adrien, J; Maire, E; Lane, BA; Curt, N; Bravin, A; Laroche, N; Badel, P; - view fewer (2023) In situ visualization of aortic dissection propagation in notched rabbit aorta using synchrotron X-ray tomography. Acta Biomaterialia , 155 pp. 449-460. 10.1016/j.actbio.2022.10.060.

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Abstract

Aortic dissection is a complex, intramural, and dynamic condition involving multiple mechanisms, hence, difficult to observe. In the present study, a controlled in vitro aortic dissection was performed using tension-inflation tests on notched rabbit aortic segments. The mechanical test was combined with conventional (cCT) and synchrotron (sCT) computed tomography for in situ imaging of the macro- and micro-structural morphological changes of the aortic wall during dissection. We demonstrate that the morphology of the notch and the aorta can be quantified in situ at different steps of the aortic dissection, and that the notch geometry correlates with the critical pressure. The phenomena prior to propagation of the notch are also described, for instance the presence of a bulge at the tip of the notch is identified, deforming the remaining wall. Finally, our method allows us to visualize for the first time the propagation of an aortic dissection in real-time with a resolution that has never previously been reached.

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