Finger, Vladimir;
Kufa, Martin;
Soukup, Ondrej;
Castagnolo, Daniele;
Roh, Jaroslav;
Korabecny, Jan;
(2023)
Pyrimidine derivatives with antitubercular activity.
European Journal of Medicinal Chemistry
, 246
, Article 114946. 10.1016/j.ejmech.2022.114946.
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Abstract
Small molecules with antitubercular activity containing the pyrimidine motif in their structure have gained more attention after three drugs, namely GSK 2556286 (GSK-286), TBA-7371 and SPR720, have entered clinical trials. This review provides an overview of recent advances in the hit-to-lead drug discovery studies of antitubercular pyrimidine-containing compounds with the aim to highlight their structural diversity. In the first part, the review discusses the pyrimidine compounds according to their targets, pinpointing the structure-activity relationships of each pyrimidine family. The second part of this review is concentrated on antitubercular pyrimidine derivatives with a yet unexplored or speculative target, dividing the compounds according to their structural types.
| Type: | Article |
|---|---|
| Title: | Pyrimidine derivatives with antitubercular activity |
| Location: | France |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ejmech.2022.114946 |
| Publisher version: | https://doi.org/10.1016/j.ejmech.2022.114946 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Drug development, Mycobacterium tuberculosis, Pyrimidine, Structure-activity relationships, Tuberculosis |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10161485 |
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