Mohari, SBM;
Taylor, KMG;
Nimmano, N;
(2022)
Preparation and characterization of curcumin-loaded liposomes for delivery to the lungs.
Thai Journal of Pharmaceutical Sciences
, 46
(3)
pp. 293-299.
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Abstract
Curcumin-loaded liposomes comprising dipalmitoylphosphatidylcholine, cholesterol, and dioleoylphosphatidylethanolamine (72:8:20 mole ratio) were prepared by the thin-film hydration method, followed by probe sonication to achieve a mean diameter <200 nm. The properties of aerosols generated using from 4 mL optimized liposome preparation filled into an air-jet nebulizer were determined using a Fast Screening Impactor (FSI) pre-cooled at 2–8°C for at least 90 min at 15 L/min. Curcumin recovered from the impactor and nebulizer was quantified using a validated high-performance liquid chromatography method. Overall, 2.5% w/w curcumin-loaded liposomes was the optimal formulation based on the maximum encapsulation efficiency of approximately 87% and mean hydrodynamic diameter of 97 nm. This chosen curcumin concentration was effectively aerosolized with a fine particle fraction of 53.25%, and a fine particle dose of 53 µg being deposited on the lower stage of the FSI (cutoff diameter 5 µm).
Type: | Article |
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Title: | Preparation and characterization of curcumin-loaded liposomes for delivery to the lungs |
Open access status: | An open access version is available from UCL Discovery |
Publisher version: | http://www.tjps.pharm.chula.ac.th/ojs/index.php/tj... |
Language: | English |
Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
Keywords: | Air-jet nebulizer, cascade impactor, curcumin, Fast Screening Impactor, liposome |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10161898 |
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