UCL Discovery Stage
UCL home » Library Services » Electronic resources » UCL Discovery Stage

Preparation and characterization of curcumin-loaded liposomes for delivery to the lungs

Mohari, SBM; Taylor, KMG; Nimmano, N; (2022) Preparation and characterization of curcumin-loaded liposomes for delivery to the lungs. Thai Journal of Pharmaceutical Sciences , 46 (3) pp. 293-299. Green open access

[thumbnail of 01-12-2022_62637501PB.pdf]
Preview
PDF
01-12-2022_62637501PB.pdf - Published Version

Download (642kB) | Preview

Abstract

Curcumin-loaded liposomes comprising dipalmitoylphosphatidylcholine, cholesterol, and dioleoylphosphatidylethanolamine (72:8:20 mole ratio) were prepared by the thin-film hydration method, followed by probe sonication to achieve a mean diameter <200 nm. The properties of aerosols generated using from 4 mL optimized liposome preparation filled into an air-jet nebulizer were determined using a Fast Screening Impactor (FSI) pre-cooled at 2–8°C for at least 90 min at 15 L/min. Curcumin recovered from the impactor and nebulizer was quantified using a validated high-performance liquid chromatography method. Overall, 2.5% w/w curcumin-loaded liposomes was the optimal formulation based on the maximum encapsulation efficiency of approximately 87% and mean hydrodynamic diameter of 97 nm. This chosen curcumin concentration was effectively aerosolized with a fine particle fraction of 53.25%, and a fine particle dose of 53 µg being deposited on the lower stage of the FSI (cutoff diameter 5 µm).

Type: Article
Title: Preparation and characterization of curcumin-loaded liposomes for delivery to the lungs
Open access status: An open access version is available from UCL Discovery
Publisher version: http://www.tjps.pharm.chula.ac.th/ojs/index.php/tj...
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Air-jet nebulizer, cascade impactor, curcumin, Fast Screening Impactor, liposome
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10161898
Downloads since deposit
1,254Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item