Martinez De La Cruz, Braulio;
Darsinou, Marousa;
Riccio, Antonella;
(2022)
From form to function: m6A methylation links mRNA structure to metabolism.
Advances in Biological Regulation
, Article 100926. 10.1016/j.jbior.2022.100926.
(In press).
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Abstract
Reversible N6-methyladenosine (m6A) RNA modification is a posttranscriptional epigenetic modification of the RNA that regulates many key aspects of RNA metabolism and function. In this review, we highlight major recent advances in the field, with special emphasis on the potential link between m6A modifications and RNA structure. We will also discuss the role of RNA methylation of neuronal transcripts, and the emerging evidence of a potential role in RNA transport and local translation in dendrites and axons of transcripts involved in synaptic functions and axon growth.
| Type: | Article |
|---|---|
| Title: | From form to function: m6A methylation links mRNA structure to metabolism |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jbior.2022.100926 |
| Publisher version: | https://doi.org/10.1016/j.jbior.2022.100926 |
| Language: | English |
| Additional information: | Copyright © 2022 Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10162166 |
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