Meadowcroft, Billie;
Palaia, Ivan;
Pfitzner, Anna-Katharina;
Roux, Aurélien;
Baum, Buzz;
Šarić, Anđela;
(2022)
Mechanochemical Rules for Shape-Shifting Filaments that Remodel Membranes.
Physical Review Letters
, 129
(26)
, Article 268101. 10.1103/physrevlett.129.268101.
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Abstract
The sequential exchange of filament composition to increase filament curvature was proposed as a mechanism for how some biological polymers deform and cut membranes. The relationship between the filament composition and its mechanical effect is lacking. We develop a kinetic model for the assembly of composite filaments that includes protein–membrane adhesion, filament mechanics and membrane mechanics. We identify the physical conditions for such a membrane remodeling and show this mechanism of sequential polymer assembly lowers the energetic barrier for membrane deformation.
| Type: | Article |
|---|---|
| Title: | Mechanochemical Rules for Shape-Shifting Filaments that Remodel Membranes |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1103/physrevlett.129.268101 |
| Publisher version: | https://doi.org/10.1103/PhysRevLett.129.268101 |
| Language: | English |
| Additional information: | This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10162440 |
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