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Whole-exome sequencing identifies genes associated with Tourette's disorder in multiplex families

Cao, Xiaolong; Zhang, Yeting; Abdulkadir, Mohamed; Deng, Li; Fernandez, Thomas; Garcia-Delgar, Blanca; Hagstrom, Julie; ... Xing, Jinchuan; + view all (2021) Whole-exome sequencing identifies genes associated with Tourette's disorder in multiplex families. Molecular Psychiatry , 26 pp. 6937-6951. 10.1038/s41380-021-01094-1. Green open access

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Abstract

Tourette’s Disorder (TD) is a neurodevelopmental disorder (NDD) that affects about 0.7% of the population and is one of the most heritable NDDs. Nevertheless, because of its polygenic nature and genetic heterogeneity, the genetic etiology of TD is not well understood. In this study, we combined the segregation information in 13 TD multiplex families with high-throughput sequencing and genotyping to identify genes associated with TD. Using whole-exome sequencing and genotyping array data, we identified both small and large genetic variants within the individuals. We then combined multiple types of evidence to prioritize candidate genes for TD, including variant segregation pattern, variant function prediction, candidate gene expression, protein–protein interaction network, candidate genes from previous studies, etc. From the 13 families, 71 strong candidate genes were identified, including both known genes for NDDs and novel genes, such as HtrA Serine Peptidase 3 (HTRA3), Cadherin-Related Family Member 1 (CDHR1), and Zinc Finger DHHC-Type Palmitoyltransferase 17 (ZDHHC17). The candidate genes are enriched in several Gene Ontology categories, such as dynein complex and synaptic membrane. Candidate genes and pathways identified in this study provide biological insight into TD etiology and potential targets for future studies.

Type: Article
Title: Whole-exome sequencing identifies genes associated with Tourette's disorder in multiplex families
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/s41380-021-01094-1
Publisher version: https://doi.org/10.1038/s41380-021-01094-1
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Genetics, Neuroscience, Psychiatric disorders
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10162636
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