Miller, Muska;
Singer, Mervyn;
(2022)
Do antibiotics cause mitochondrial and immune cell dysfunction? A literature review.
Journal of Antimicrobial Chemotherapy
, 77
(5)
pp. 1218-1227.
10.1093/jac/dkac025.
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Abstract
While antibiotics are clearly important treatments for infection, antibiotic-induced modulation of the immune system can have detrimental effects on pathogen clearance and immune functionality, increasing the risk of secondary infection. These injurious consequences may be mediated, at least in part, through effects on the mitochondria, the functioning of which is already compromised by the underlying septic process. Here, we review the complex interactions between antibiotic administration, immune cell and mitochondrial dysfunction.
| Type: | Article |
|---|---|
| Title: | Do antibiotics cause mitochondrial and immune cell dysfunction? A literature review |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1093/jac/dkac025 |
| Publisher version: | https://doi.org/10.1093/jac/dkac025 |
| Language: | English |
| Additional information: | © The Author(s) 2022. Published by Oxford University Press on behalf of British Society for Antimicrobial Chemotherapy. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | BETA-LACTAM ANTIBIOTICS, BRONCHOALVEOLAR LAVAGE FLUID, Infectious Diseases, IN-VITRO ACTIVITY, Life Sciences & Biomedicine, Microbiology, NECROSIS-FACTOR-ALPHA, NEUTROPHILIC AIRWAY INFLAMMATION, Pharmacology & Pharmacy, POLYMORPHONUCLEAR LEUKOCYTE FUNCTION, REDUCES BRONCHIAL HYPERRESPONSIVENESS, RENAL CORTICAL MITOCHONDRIA, RESISTANT STAPHYLOCOCCUS-AUREUS, Science & Technology, SUPEROXIDE ANION PRODUCTION |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10162766 |
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