Zaaimi, B;
Turnbull, M;
Hazra, A;
Wang, Y;
Gandara, C;
McLeod, F;
McDermott, EE;
... Jackson, A; + view all
(2023)
Closed-loop optogenetic control of the dynamics of neural activity in non-human primates.
Nature Biomedical Engineering
, 7
pp. 559-575.
10.1038/s41551-022-00945-8.
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Abstract
Electrical neurostimulation is effective in the treatment of neurological disorders, but associated recording artefacts generally limit its applications to open-loop stimuli. Real-time and continuous closed-loop control of brain activity can, however, be achieved by pairing concurrent electrical recordings and optogenetics. Here we show that closed-loop optogenetic stimulation with excitatory opsins enables the precise manipulation of neural dynamics in brain slices from transgenic mice and in anaesthetized non-human primates. The approach generates oscillations in quiescent tissue, enhances or suppresses endogenous patterns in active tissue and modulates seizure-like bursts elicited by the convulsant 4-aminopyridine. A nonlinear model of the phase-dependent effects of optical stimulation reproduced the modulation of cycles of local-field potentials associated with seizure oscillations, as evidenced by the systematic changes in the variability and entropy of the phase-space trajectories of seizures, which correlated with changes in their duration and intensity. We also show that closed-loop optogenetic neurostimulation could be delivered using intracortical optrodes incorporating light-emitting diodes. Closed-loop optogenetic approaches may be translatable to therapeutic applications in humans.
| Type: | Article |
|---|---|
| Title: | Closed-loop optogenetic control of the dynamics of neural activity in non-human primates |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s41551-022-00945-8 |
| Publisher version: | https://doi.org/10.1038/s41551-022-00945-8 |
| Language: | English |
| Keywords: | Biomedical engineering, Computational neuroscience, Epilepsy, Neural circuits |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10162774 |
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