Thong, Phan Quoc;
Huong, Le Thi Thu;
Tu, Nguyen Dac;
Nhung, Hoang Thi My;
Khanh, Lam;
Manh, Do Hung;
Nam, Pham Hong;
... Thanh, Nguyen Thi Kim; + view all
(2023)
Multifunctional nanocarriers of Fe3O4@PLA-PEG/curcumin for MRI, magnetic hyperthermia and drug delivery.
Nanomedicine
, 17
(22)
pp. 1677-1693.
10.2217/nnm-2022-0070.
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Abstract
Background: Despite medicinal advances, cancer is still a big problem requiring better diagnostic and treatment tools. Magnetic nanoparticle (MNP)-based nanosystems for multiple-purpose applications were developed for these unmet needs. Methods: This study fabricated novel trifunctional MNPs of Fe3O4@PLA-PEG for drug release, MRI and magnetic fluid hyperthermia. Result: The MNPs provided a significant loading of curcumin (∼11%) with controllable release ability, a high specific absorption rate of 82.2 W/g and significantly increased transverse relaxivity (r2 = 364.75 mM-1 s-1). The in vivo study confirmed that the MNPs enhanced MRI contrast in tumor observation and low-field magnetic fluid hyperthermia could effectively reduce the tumor size in mice bearing sarcoma 180. Conclusion: The nanocarrier has potential for drug release, cancer treatment monitoring and therapy.
| Type: | Article |
|---|---|
| Title: | Multifunctional nanocarriers of Fe3O4@PLA-PEG/curcumin for MRI, magnetic hyperthermia and drug delivery |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2217/nnm-2022-0070 |
| Publisher version: | https://doi.org/10.2217/nnm-2022-0070 |
| Language: | English |
| Additional information: | This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biotechnology & Applied Microbiology, Nanoscience & Nanotechnology, Science & Technology - Other Topics, curcumin, drug delivery, Fe3O4 nanoparticles, hyperthermia, MRI, SUPERPARAMAGNETIC IRON-OXIDE, FE3O4 NANOPARTICLES, CONTRAST AGENTS, COMPUTER-SIMULATIONS, CANCER-TREATMENT, T-2 RELAXATION, RESONANCE, RELEASE, NANOTECHNOLOGY, ENHANCEMENT |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10165108 |
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