Uchitel, Julie;
Blanco, Borja;
Collins-Jones, Liam;
Edwards, Andrea;
Porter, Emma;
Pammenter, Kelle;
Hebden, Jem;
... Austin, Topun; + view all
(2023)
Cot-side imaging of functional connectivity in the developing brain during sleep using wearable high-density diffuse optical tomography.
NeuroImage
, 265
, Article 119784. 10.1016/j.neuroimage.2022.119784.
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Abstract
Studies of cortical function in newborn infants in clinical settings are extremely challenging to undertake with traditional neuroimaging approaches. Partly in response to this challenge, functional near-infrared spectroscopy (fNIRS) has become an increasingly common clinical research tool but has significant limitations including a low spatial resolution and poor depth specificity. Moreover, the bulky optical fibres required in traditional fNIRS approaches present significant mechanical challenges, particularly for the study of vulnerable newborn infants. A new generation of wearable, modular, high-density diffuse optical tomography (HD-DOT) technologies has recently emerged that overcomes many of the limitations of traditional, fibre-based and low-density fNIRS measurements. Driven by the development of this new technology, we have undertaken the first cot-side study of newborn infants using wearable HD-DOT in a clinical setting. We use this technology to study functional brain connectivity (FC) in newborn infants during sleep and assess the effect of neonatal sleep states, active sleep (AS) and quiet sleep (QS), on resting state FC. Our results demonstrate that it is now possible to obtain high-quality functional images of the neonatal brain in the clinical setting with few constraints. Our results also suggest that sleep states differentially affect FC in the neonatal brain, consistent with prior reports.
| Type: | Article |
|---|---|
| Title: | Cot-side imaging of functional connectivity in the developing brain during sleep using wearable high-density diffuse optical tomography |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.neuroimage.2022.119784 |
| Publisher version: | https://doi.org/10.1016/j.neuroimage.2022.119784 |
| Language: | English |
| Additional information: | © 2023 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Neurosciences, Neuroimaging, Radiology, Nuclear Medicine & Medical Imaging, Neurosciences & Neurology, High-density diffuse optical tomography, HD-DOT, Cot-side neuroimaging, Newborn neuroimaging, Resting state functional connectivity, Functional connectivity, Newborn sleep states, NEAR-INFRARED SPECTROSCOPY, RESTING-STATE NETWORKS, PRETERM INFANTS, EEG-SLEEP, TERM, HEMODYNAMICS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10165460 |
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