Rodríguez-Pombo, L;
Martínez-Castro, L;
Xu, X;
Ong, JJ;
Rial, C;
García, DN;
González-Santos, A;
... Goyanes, A; + view all
(2023)
Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing.
International Journal of Pharmaceutics: X
, 5
, Article 100166. 10.1016/j.ijpx.2023.100166.
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Abstract
3D printing is driving a shift in patient care away from a generalised model and towards personalised treatments. To complement fast-paced clinical environments, 3D printing technologies must provide sufficiently high throughputs for them to be feasibly implemented. Volumetric printing is an emerging 3D printing technology that affords such speeds, being capable of producing entire objects within seconds. In this study, for the first time, rotatory volumetric printing was used to simultaneously produce two torus- or cylinder-shaped paracetamol-loaded Printlets (3D printed tablets). Six resin formulations comprising paracetamol as the model drug, poly(ethylene glycol) diacrylate (PEGDA) 575 or 700 as photoreactive monomers, water and PEG 300 as non-reactive diluents, and lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) as the photoinitiator were investigated. Two printlets were successfully printed in 12 to 32 s and exhibited sustained drug release profiles. These results support the use of rotary volumetric printing for efficient and effective manufacturing of various personalised medicines at the same time. With the speed and precision it affords, rotatory volumetric printing has the potential to become one of the most promising alternative manufacturing technologies in the pharmaceutical industry.
| Type: | Article |
|---|---|
| Title: | Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ijpx.2023.100166 |
| Publisher version: | https://doi.org/10.1016/j.ijpx.2023.100166 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Vat photopolymerization 3D printed medicines, 3D rotary printing, Tomographic reconstruction, 3D printed drug products, Printing pharmaceuticals and drug delivery systems, Personalized formulations |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10165659 |
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