Wilson, DM;
Cookson, MR;
Van Den Bosch, L;
Zetterberg, H;
Holtzman, DM;
Dewachter, I;
(2023)
Hallmarks of neurodegenerative diseases.
Cell
, 186
(4)
pp. 693-714.
10.1016/j.cell.2022.12.032.
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Abstract
Decades of research have identified genetic factors and biochemical pathways involved in neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks of NDD: pathological protein aggregation, synaptic and neuronal network dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy homeostasis, DNA and RNA defects, inflammation, and neuronal cell death. We describe the hallmarks, their biomarkers, and their interactions as a framework to study NDDs using a holistic approach. The framework can serve as a basis for defining pathogenic mechanisms, categorizing different NDDs based on their primary hallmarks, stratifying patients within a specific NDD, and designing multi-targeted, personalized therapies to effectively halt NDDs.
| Type: | Article |
|---|---|
| Title: | Hallmarks of neurodegenerative diseases |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cell.2022.12.032 |
| Publisher version: | https://doi.org/10.1016/j.cell.2022.12.032 |
| Language: | English |
| Additional information: | © 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keywords: | DNA and RNA defects, cytoskeletal defects, energy homeostasis, hallmarks, inflammation, neurodegeneration, neurodegenerative disease, protein aggregation, proteostasis, synaptic and neuronal network dysfunction, Humans, Neurodegenerative Diseases, Proteostasis, Protein Aggregation, Pathological, Cell Death, Cytoskeleton |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10165783 |
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