Gerin, Mattia;
Viding, Essi;
Puetz, Vanessa;
Armbruster-Genc, Diana;
Rankin, Georgia;
McCrory, Eamon;
(2023)
Atypical Interpersonal Problem-Solving and Resting-State Functional Connectivity in Adolescents with Maltreatment Experience.
Current Neuropharmacology
, 22
(2)
pp. 290-301.
10.2174/1570159X22666231002145440.
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Abstract
BACKGROUND: Childhood maltreatment is associated with altered neurocognitive functioning, which is thought to reflect, in part, adaptation to early adverse environmental experiences. However, we continue to lack a precise mechanistic understanding linking atypical neurocognitive processing with social functioning and psychiatric outcomes following early adversity. OBJECTIVE: The present work investigated interpersonal problem-solving, resting-state functional connectivity (rsFC), and mental health symptoms in adolescents with documented maltreatment experience and explored whether altered neural function contributes in part to poorer social functioning. METHODS: Forty adolescents (aged 12-17) with documented experiences of abuse or neglect and a carefully matched group of 42 non-maltreated peers participated in this study that measured task-based interpersonal problem-solving skills and rsFC. RESULTS: Adolescents with maltreatment experience showed poorer interpersonal problem-solving performance, which partly accounted for their elevated mental health symptoms. Resting-state seed-based analyses revealed that adolescents with maltreatment experience showed a significant increase in rsFC between medial Default Mode Network (DMN) hubs, the medial prefrontal cortex (mPFC), with a posterior cluster, including the posterior cingulate cortex (PCC), precuneus (PCu), retrosplenial cortex (RSC), and lingual gyrus (LG). Moderation analyses revealed that maltreatment-related increased DMN rsFC partly accounted for poorer performance in interpersonal problem-solving. CONCLUSION: Poorer interpersonal problem-solving, partly accounted for by atypical coupling between DMN medial hubs, was associated with maltreatment exposure. Interventions tailored to enhance interpersonal problem-solving represents a promising avenue to promote resilience and reduce the likelihood of mental health disorder following maltreatment experience.
| Type: | Article |
|---|---|
| Title: | Atypical Interpersonal Problem-Solving and Resting-State Functional Connectivity in Adolescents with Maltreatment Experience |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2174/1570159X22666231002145440 |
| Publisher version: | http://dx.doi.org/10.2174/1570159X2266623100214544... |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Childhood maltreatment, childhood trauma, social functioning, interpersonal problem-solving, functional magnetic resonance imaging (fMRI), resting-state functional connectivity (rsFC), default mode network (DMN), medial prefrontal cortex (mPFC) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10166302 |
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