Smith, EMD;
Aggarwal, A;
Ainsworth, J;
Al-Abadi, E;
Avcin, T;
Bortey, L;
Burnham, J;
... Beresford, MW; + view all
(2023)
PReS-endorsed International Childhood Lupus T2T Task Force definition of Childhood Lupus Low Disease Activity State (cLLDAS).
Clinical Immunology
, 250
, Article 109296. 10.1016/j.clim.2023.109296.
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Abstract
OBJECTIVE: To achieve a consensus-based definition of Low Disease Activity (LDA) for use in cSLE trials. METHODS: The International cSLE T2T Task Force, comprising of paediatric rheumatologists/nephrologists, and adult rheumatologists undertook a series of Delphi surveys/consensus meetings to discuss, refine, and vote upon cSLE LDA criteria. RESULTS: The Task Force agreed that LDA should be based upon the adult-SLE Lupus Low Disease Activity State definition (LLDAS), with modifications to make it applicable to cSLE (cLLDAS). They agreed upon five cLLDAS criteria: (1) SLE Disease Activity Index (SLEDAI)-2 K ≤4, with no activity in major organ systems; (2) no new features of lupus disease activity compared with the last assessment; (3) Physician Global Assessment score of ≤1 (0–3 scale); (4) prednisolone dose of ≤0.15 mg/kg/day, 7.5 mg/day/maximum; while on (5) stable antimalarials, immunosuppressives, and biologics. CONCLUSIONS: A cSLE-appropriate definition of cLLDAS has been generated, maintaining alignment with the adult-SLE definition to promote life-course research.
| Type: | Article |
|---|---|
| Title: | PReS-endorsed International Childhood Lupus T2T Task Force definition of Childhood Lupus Low Disease Activity State (cLLDAS) |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.clim.2023.109296 |
| Publisher version: | https://doi.org/10.1016/j.clim.2023.109296 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Treat-to-target, T2T, cSLE, childhood-SLE, low disease activity, cLLDAS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Inflammation |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10166340 |
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