Lee Pow, Joni;
Donald, Casswina;
di Forti, Marta;
Roberts, Tessa;
Weiss, Helen A;
Ayinde, Olatunde;
John, Sujit;
... Hutchinson, Gerard; + view all
(2023)
Cannabis use and psychotic disorders in diverse settings in the Global South: findings from INTREPID II.
Psychological Medicine
pp. 1-8.
10.1017/s0033291723000399.
(In press).
Preview |
PDF
cannabis-use-and-psychotic-disorders-in-diverse-settings-in-the-global-south-findings-from-intrepid-ii.pdf - Published Version Download (335kB) | Preview |
Abstract
Background Cannabis use has been linked to psychotic disorders but this association has been primarily observed in the Global North. This study investigates patterns of cannabis use and associations with psychoses in three Global South (regions within Latin America, Asia, Africa and Oceania) settings. Methods Case–control study within the International Programme of Research on Psychotic Disorders (INTREPID) II conducted between May 2018 and September 2020. In each setting, we recruited over 200 individuals with an untreated psychosis and individually-matched controls (Kancheepuram India; Ibadan, Nigeria; northern Trinidad). Controls, with no past or current psychotic disorder, were individually-matched to cases by 5-year age group, sex and neighbourhood. Presence of psychotic disorder assessed using the Schedules for Clinical Assessment in Neuropsychiatry and cannabis exposure measured by the World Health Organisation Alcohol, Smoking and Substance Involvement Screening Test (ASSIST). Results Cases reported higher lifetime and frequent cannabis use than controls in each setting. In Trinidad, cannabis use was associated with increased odds of psychotic disorder: lifetime cannabis use (adj. OR 1.58, 95% CI 0.99–2.53); frequent cannabis use (adj. OR 1.99, 95% CI 1.10–3.60); cannabis dependency (as measured by high ASSIST score) (adj. OR 4.70, 95% CI 1.77–12.47), early age of first use (adj. OR 1.83, 95% CI 1.03–3.27). Cannabis use in the other two settings was too rare to examine associations. Conclusions In line with previous studies, we found associations between cannabis use and the occurrence and age of onset of psychoses in Trinidad. These findings have implications for strategies for prevention of psychosis.
| Type: | Article |
|---|---|
| Title: | Cannabis use and psychotic disorders in diverse settings in the Global South: findings from INTREPID II |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1017/s0033291723000399 |
| Publisher version: | https://doi.org/10.1017/s0033291723000399 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Psychosis, schizophrenia, first-onset, cannabis, global mental health |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10167303 |
Archive Staff Only
 |
View Item |
