Gong, Xin;
Yu, Na;
Gu, Linghui;
Li, Zheyu;
Ma, Wenbo;
Zhao, Fei;
(2023)
Redox-neutral rhodium(iii)-catalyzed divergent synthesis of tetrasubstituted 1,3-enynes and alkynylated benzofurans.
Organic and Biomolecular Chemistry
, 21
(1)
pp. 147-152.
10.1039/d2ob01800d.
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Abstract
With the assistance of the acetamido directing group (DG), a rhodium-catalyzed C–H alkenylation/DG migration cascade for the synthesis of tetrasubstituted 1,3-enynes from N-phenoxyacetamides and 1,3-diynes has been achieved in this work. Alternatively, a rhodium-catalyzed [3 + 2] annulation for the synthesis of alkynylated benzofurans from the same set of substrates has also been achieved by simply changing the reaction conditions. This work highlights the tunable divergent synthesis of valuable compounds triggered by C–H activation.
| Type: | Article |
|---|---|
| Title: | Redox-neutral rhodium(iii)-catalyzed divergent synthesis of tetrasubstituted 1,3-enynes and alkynylated benzofurans |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/d2ob01800d |
| Publisher version: | https://doi.org/10.1039/D2OB01800D |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10167629 |
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