Wu, Xiaowei;
Li, Pinyi;
Lu, Yangbin;
Qiao, Jin;
Zhao, Jingwei;
Jia, Xiuwen;
Ni, Hangcheng;
... Zhao, Fei; + view all
(2020)
Rhodium-Catalyzed Cascade Reactions of Indoles with 4-
Hydroxy-2-Alkynoates for the Synthesis of Indole-Fused
Polyheterocycles.
Advanced Synthesis & Catalysis (ASC)
, 362
(14)
pp. 2953-2960.
10.1002/adsc.202000493.
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Abstract
Herein, an efficient and regioselective Rh(III)-catalyzed [4+2] annulation/lactonization cascade of indoles with 4-hydroxy-2-alkynoates at room temperature to access the furo[3′,4′:4,5]pyrimido[1,6-a]indole-1,5(3H,4H)-diones is described. This method features mild reaction conditions, operational simplicity, excellent regioselectivity, broad substrate scope with good functional group tolerance, and good to excellent yields.
| Type: | Article |
|---|---|
| Title: | Rhodium-Catalyzed Cascade Reactions of Indoles with 4- Hydroxy-2-Alkynoates for the Synthesis of Indole-Fused Polyheterocycles |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/adsc.202000493 |
| Publisher version: | https://doi.org/10.1002/adsc.202000493 |
| Language: | English |
| Additional information: | This version is the author-accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Rhodium; CH activation; Cascadereaction; [4+2] annulation; Lactonization |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10167672 |
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