Liu, Siyu;
Mao, Hui;
Qiao, Jin;
Zhang, Xiaoning;
Lu, Yangbin;
Gong, Xin;
Jia, Aiqiong;
... Zhao, Fei; + view all
(2021)
Temperature-Controlled Divergent Synthesis of Tetrasubstituted Alkenes and Pyrrolo[1,2-a]indole Derivatives via Iridium Catalysis.
Asian Journal of Organic Chemistry
, 10
(12)
pp. 3308-3320.
10.1002/ajoc.202100476.
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Abstract
We have achieved an Ir(III)-catalyzed temperature-controlled divergent synthesis of tetrasubstituted alkenes and pyrrolo[1,2-a]indole derivatives through C−H alkenylation/DG migration and [3+2] annulation, respectively. This method has various advantageous features: a) excellent regio- and stereoselectivity and good functional group tolerance, b) broad substrate scope and moderate to excellent yields, c) mild redox-neutral reaction conditions and operational simplicity.
| Type: | Article |
|---|---|
| Title: | Temperature-Controlled Divergent Synthesis of Tetrasubstituted Alkenes and Pyrrolo[1,2-a]indole Derivatives via Iridium Catalysis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/ajoc.202100476 |
| Publisher version: | https://doi.org/10.1002/ajoc.202100476 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | Iridium, C−H activation, [3+2] annulation, Tetrasubstituted alkene, pyrrolo[1,2-a]indole |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10167710 |
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