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Oxazolidinones as versatile scaffolds in medicinal chemistry

Fernandes, Guilherme Felipe Santos; Scarim, Cauê Benito; Kim, Seong-Heun; Wu, Jingyue; Castagnolo, Daniele; (2023) Oxazolidinones as versatile scaffolds in medicinal chemistry. RSC Medicinal Chemistry 10.1039/d2md00415a. (In press). Green open access

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Abstract

Oxazolidinone is a five-member heterocyclic ring with several biological applications in medicinal chemistry. Among the three possible isomers, 2-oxazolidinone is the most investigated in drug discovery. Linezolid was pioneered as the first approved drug containing an oxazolidinone ring as the pharmacophore group. Numerous analogues have been developed since its arrival on the market in 2000. Some have succeeded in reaching the advanced stages of clinical studies. However, most oxazolidinone derivatives reported in recent decades have not reached the initial stages of drug development, despite their promising pharmacological applications in a variety of therapeutic areas, including antibacterial, antituberculosis, anticancer, anti-inflammatory, neurologic, and metabolic diseases, among other areas. Therefore, this review article aims to compile the efforts of medicinal chemists who have explored this scaffold over the past decades and highlight the potential of the class for medicinal chemistry.

Type: Article
Title: Oxazolidinones as versatile scaffolds in medicinal chemistry
Open access status: An open access version is available from UCL Discovery
DOI: 10.1039/d2md00415a
Publisher version: https://doi.org/10.1039/d2md00415a
Language: English
Additional information: © The Author(s) 2023. This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence (https://creativecommons.org/licenses/by-nc/3.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10168012
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