Perosa, V;
Rotta, J;
Yakupov, R;
Kuijf, HJ;
Schreiber, F;
Oltmer, JT;
Mattern, H;
... Schreiber, S; + view all
(2023)
Implications of quantitative susceptibility mapping at 7 Tesla MRI for microbleeds detection in cerebral small vessel disease.
Frontiers in Neurology
, 14
, Article 1112312. 10.3389/fneur.2023.1112312.
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Abstract
BACKGROUND: Cerebral microbleeds (MBs) are a hallmark of cerebral small vessel disease (CSVD) and can be found on T2*-weighted sequences on MRI. Quantitative susceptibility mapping (QSM) is a postprocessing method that also enables MBs identification and furthermore allows to differentiate them from calcifications. AIMS: We explored the implications of using QSM at submillimeter resolution for MBs detection in CSVD. METHODS: Both 3 and 7 Tesla (T) MRI were performed in elderly participants without MBs and patients with CSVD. MBs were quantified on T2*-weighted imaging and QSM. Differences in the number of MBs were assessed, and subjects were classified in CSVD subgroups or controls both on 3T T2*-weighted imaging and 7T QSM. RESULTS: 48 participants [mean age (SD) 70.9 (8.8) years, 48% females] were included: 31 were healthy controls, 6 probable cerebral amyloid angiopathy (CAA), 9 mixed CSVD, and 2 were hypertensive arteriopathy [HA] patients. After accounting for the higher number of MBs detected at 7T QSM (Median = Mdn; Mdn7T−QSM = 2.5; Mdn3T−T2 = 0; z = 4.90; p < 0.001) and false positive MBs (6.1% calcifications), most healthy controls (80.6%) demonstrated at least one MB and more MBs were discovered in the CSVD group. CONCLUSIONS: Our observations suggest that QSM at submillimeter resolution improves the detection of MBs in the elderly human brain. A higher prevalence of MBs than so far known in healthy elderly was revealed.
| Type: | Article |
|---|---|
| Title: | Implications of quantitative susceptibility mapping at 7 Tesla MRI for microbleeds detection in cerebral small vessel disease |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fneur.2023.1112312 |
| Publisher version: | https://doi.org/10.3389/fneur.2023.1112312 |
| Language: | English |
| Additional information: | © 2023 Perosa, Rotta, Yakupov, Kuijf, Schreiber, Oltmer, Mattern, Heinze, Düzel and Schreiber. This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | 7 Tesla MRI, cerebral small vessel disease (CSVD), cerebral amyloid angiopathy (CAA), microbleeds, quantitative susceptibility mapping (QSM), hypertensive arteriopathy (HA) |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Institute of Cognitive Neuroscience |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10168314 |
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