Valdebenito, Gabriel E;
Chacko, Anitta R;
Duchen, Michael R;
(2023)
The mitochondrial ATP synthase as an ATP consumer—a surprising therapeutic target.
The EMBO Journal
, Article e114141. 10.15252/embj.2023114141.
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Abstract
The mitochondrial F1Fo-ATP synthase uses a rotary mechanism to synthesise ATP. This mechanism can, however, also operate in reverse, pumping protons at the expense of ATP, with significant potential implications for mitochondrial and age-related diseases. In a recent study, Acin-Perez et al (2023) use an elegant assay to screen compounds for the capacity to selectively inhibit ATP hydrolysis without affecting ATP synthesis. They show that (+)-epicatechin is one such compound and has significant benefits for cell and tissue function in disease models. These findings signpost a novel therapeutic approach for mitochondrial disease.
| Type: | Article |
|---|---|
| Title: | The mitochondrial ATP synthase as an ATP consumer—a surprising therapeutic target |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.15252/embj.2023114141 |
| Publisher version: | https://doi.org/10.15252/embj.2023114141 |
| Language: | English |
| Additional information: | © 2023 The Authors. Published under the terms of the CC BY 4.0 license (https://creativecommons.org/licenses/by/4.0/). |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10168404 |
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