Kallitsis, K;
Pappa, AM;
Lu, Z;
Alvarez-Fernandez, A;
Charalambous, I;
Schack, S;
Traberg, WC;
... Owens, RM; + view all
(2023)
Tailoring the Surface Chemistry of PEDOT:PSS to Promote Supported Lipid Bilayer Formation.
Macromolecular Materials and Engineering
, Article 2300038. 10.1002/mame.202300038.
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Abstract
This communication reports on a versatile and substrate-agnostic method to tune the surface chemistry of conducting polymers with the aim of bridging the chemical mismatch between bioelectronic devices and biological systems. As a proof of concept, the surface of poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) is grafted with a short-chain oligoethylene glycol monolayer to favor the formation of cell-derived supported lipid bilayers (SLBs). This method is tuned to optimize the affinity between the supported lipid bilayer and the conducting polymer, leading to significant improvements in bilayer quality and therefore electronic readouts. To validate the impact of surface functionalization on the system's ability to transduce biological phenomena into quantifiable electronic signals, the activity of a virus commonly used as a surrogate for SARS-CoV-2 (mouse hepatitis virus) is monitored with and without surface treatment. The functionalized devices exhibit significant improvements in electronic output, stemming from the improved SLB quality, therefore strengthening the case for the use of such an approach in membrane-on-a-chip systems.
| Type: | Article |
|---|---|
| Title: | Tailoring the Surface Chemistry of PEDOT:PSS to Promote Supported Lipid Bilayer Formation |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/mame.202300038 |
| Publisher version: | https://doi.org/10.1002/mame.202300038 |
| Language: | English |
| Additional information: | © 2023 The Authors. Macromolecular Materials and Engineering published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Conducting polymers, supported lipid bilayers, organic bioelectronics, surface functionalization, virus detection |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Chemical Engineering |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10169005 |
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