Mpotje, T;
More, J;
Rajkumar-Bhugeloo, K;
Moodley, D;
Marakalala, MJ;
(2023)
Validation of proteins associated with pathological damage in human tuberculosis granulomas: study protocol [version 1; peer review: 2 approved].
Wellcome Open Research
, 8
, Article 139. 10.12688/wellcomeopenres.19226.1.
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Abstract
The presence of the Tuberculosis (TB) disease-causing pathogen, Mycobacterium Tuberculosis (Mtb), induces the development of a pathological feature termed granuloma, which the host uses to contain the bacteria. However, the granuloma may dissociate resulting in detrimental caseation of the lung. The disease contributes to a growing global burden of lung function challenges, warranting for more understanding of the TB-induced immunopathology. The current study aims to explore in detail host factors that drive pathological features of TB contributing to extensive lung tissue destruction. Lung tissue sections obtained from patients undergoing surgical resection will be processed and analyzed using histopathological assays including Immunohistochemistry, Immunofluorescence, Hematoxylin and Eosin staining and Laser Capture Microdissection. The findings will provide key host factors that associate with exacerbated lung immunopathology during TB.
| Type: | Article |
|---|---|
| Title: | Validation of proteins associated with pathological damage in human tuberculosis granulomas: study protocol [version 1; peer review: 2 approved] |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.12688/wellcomeopenres.19226.1 |
| Publisher version: | https://doi.org/10.12688/wellcomeopenres.19226.1 |
| Language: | English |
| Additional information: | Copyright © 2023 Mpotje T et al. This is an open access work distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Host-Directed Therapies, Inflammation, Lung pathology, Mycobacterium tuberculosis, TB Granulomas |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10169208 |
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