Ma, Jingyi;
Todd, Matthew;
van de Sande, Wendy WJ;
Biersack, Bernhard;
(2023)
Antifungal Activity of Natural Naphthoquinones and Anthraquinones against Madurella mycetomatis.
Chemistry and Biodiversity
, Article e202300151. 10.1002/cbdv.202300151.
(In press).
Preview |
Text
Chemistry Biodiversity - 2023 - Ma - Antifungal Activity of Natural Naphthoquinones and Anthraquinones against Madurella.pdf - Published Version Download (662kB) | Preview |
Abstract
Eumycetoma, the fungal form of the neglected tropical disease mycetoma, is a crippling infectious disease with low response rates to currently available antifungal drugs. In this study, a series of natural naphthoquinones and anthraquinones was evaluated for their activity against Madurella mycetomatis, which is the most common causative agent of eumycetoma. The metabolic activity of Madurella mycetomatis as well as the viability of Galleria mellonella larvae upon treatment with quinones was investigated. Several hydroxy-substituted naphthoquinones exhibited activity against Madurella mycetomatis. In particular, naphthazarin (5,8-dihydroxy-1,4-naphthoquinone) was identified as a considerably active antifungal compound against Madurella mycetomatis (IC50=1.4 μM), while it showed reduced toxicity to Galleria mellonella larvae, which is a well-established in vivo invertebrate model for mycetoma drug studies.
| Type: | Article |
|---|---|
| Title: | Antifungal Activity of Natural Naphthoquinones and Anthraquinones against Madurella mycetomatis |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/cbdv.202300151 |
| Publisher version: | https://doi.org/10.1002/cbdv.202300151 |
| Language: | English |
| Additional information: | © 2023 The Authors. Chemistry & Biodiversity published by Wiley-VHCA AG, Zurich, Switzerland This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. http://creativecommons.org/licenses/by-nc/4.0/. |
| Keywords: | antifungal, eumycetoma, naphthazarin, naphthoquinone, neglected tropical disease |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharma and Bio Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10169404 |
Archive Staff Only
 |
View Item |
