Nebgen, Denise R;
Domchek, Susan M;
Kotsopoulos, Joanne;
de Hullu, Joanne A;
Crosbie, Emma J;
Paramanandam, Vincent Singh;
van Zanten, Monique Brood;
... Hickey, Martha; + view all
(2023)
Care after premenopausal risk-reducing salpingo-oophorectomy in high-risk women: Scoping review and international consensus recommendations.
BJOG: an International Journal of Obstetrics & Gynaecology
10.1111/1471-0528.17511.
(In press).
Preview |
PDF
Care after premenopausal risk reducing salpingo oophorectomy.pdf - Published Version Download (1MB) | Preview |
Abstract
Women at high inherited risk of ovarian cancer are offered risk-reducing salpingo-oophorectomy (RRSO) from age 35 to 45 years. Although potentially life-saving, RRSO may induce symptoms that negatively affect quality of life and impair long-term health. Clinical care following RRSO is often suboptimal. This scoping review describes how RRSO affects short- and long-term health and provides evidence-based international consensus recommendations for care from preoperative counselling to long-term disease prevention. This includes the efficacy and safety of hormonal and non-hormonal treatments for vasomotor symptoms, sleep disturbance and sexual dysfunction and effective approaches to prevent bone and cardiovascular disease.
| Type: | Article |
|---|---|
| Title: | Care after premenopausal risk-reducing salpingo-oophorectomy in high-risk women: Scoping review and international consensus recommendations |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/1471-0528.17511 |
| Publisher version: | http://doi.org/10.1111/1471-0528.17511 |
| Language: | English |
| Additional information: | © 2023 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | BRCA1, BRCA2, early menopause, hormone replacement therapy, hot flushes, ovarian cancer, risk-reducing salpingo-oophorectomy, sexual function, surgical menopause |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Inst of Clinical Trials and Methodology > MRC Clinical Trials Unit at UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10169785 |
Archive Staff Only
 |
View Item |
