Ogbunuzor, Christopher;
Fransen, Leonie Francina Hendrina;
Talibi, Midhat;
Khan, Zuhaib;
Dalzell, Abigail;
Laycock, Adam;
Southern, Daniel;
... Leonard, Martin Oliver; + view all
(2023)
Biodiesel exhaust particle airway toxicity and the role of polycyclic aromatic hydrocarbons.
Ecotoxicology and Environmental Safety
, 259
, Article 115013. 10.1016/j.ecoenv.2023.115013.
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Abstract
Renewable alternatives to fossil diesel (FD) including fatty acid methyl ester (FAME) biodiesel have become more prevalent. However, toxicity of exhaust material from their combustion, relative to the fuels they are displacing has not been fully characterised. This study was carried out to examine particle toxicity within the lung epithelium and the role for polycyclic aromatic hydrocarbons (PAHs). Exhaust particles from a 20% (v/v) blend of FAME biodiesel had little impact on primary airway epithelial toxicity compared to FD derived particles but did result in an altered profile of PAHs, including an increase in particle bound carcinogenic B[a]P. Higher blends of biodiesel had significantly increased levels of more carcinogenic PAHs, which was associated with a higher level of stress response gene expression including CYP1A1, NQO1 and IL1B. Removal of semi-volatile material from particulates abolished effects on airway cells. Particle size difference and toxic metals were discounted as causative for biological effects. Finally, combustion of a single component fuel (Methyl decanoate) containing the methyl ester molecular structure found in FAME mixtures, also produced more carcinogenic PAHs at the higher fuel blend levels. These results indicate the use of FAME biodiesel at higher blends may be associated with an increased particle associated carcinogenic and toxicity risk.
| Type: | Article |
|---|---|
| Title: | Biodiesel exhaust particle airway toxicity and the role of polycyclic aromatic hydrocarbons |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ecoenv.2023.115013 |
| Publisher version: | https://doi.org/10.1016/j.ecoenv.2023.115013 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Pollutant, Lung, Epithelial, Biodiesel, Particulate matter |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10169955 |
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