Martin, Liam T;
Lamming, Eleanor D;
Maitra, Arundhati;
Mortazavi, Parisa N;
Roddan, Rebecca;
Ward, John M;
Bhakta, Sanjib;
(2023)
C-1 Substituted isoquinolines potentiate the antimycobacterial activity of rifampicin and ethambutol.
Frontiers in Antibiotics
, 2
, Article 1095013. 10.3389/frabi.2023.1095013.
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Abstract
Introduction: The emergence of extensively drug-resistant strains of Mycobacterium tuberculosis threatens decades of progress in the treatment of a disease which remains one of the leading infectious causes of death worldwide. The development of novel antimycobacterial compounds is therefore essential to reinforce the existing antitubercular drug discovery pipeline. There is also interest in new compounds which can synergize with existing antitubercular drugs and can be deployed as part of a combination therapy. This strategy could serve to delay the emergence of resistance to first-line anti-tuberculosis drugs and increase their efficacy against resistant strains of tuberculosis. Previous research has established that several C-1 substituted tetrahydroisoquinolines have antimycobacterial activity. Here we sought to expand our understanding of their antimycobacterial structure activity relationships and their potential to act as adjunct therapies alongside existing antitubercular drugs./ Methods: Three chemical series were synthesised and assayed for their antimycobacterial potency, mammalian cell toxicity, inhibition of whole-cell efflux and synergism with isoniazid, rifampicin, and ethambutol. Results: Several compounds were found to inhibit the growth of mycobacteria. Potent inhibitors of whole-cell efflux were also identified, as well as compounds which exhibited synergism with rifampicin and ethambutol./ Conclusions: Structure-activity relationships were identified for antimycobacterial potency, improved selectivity, whole cell efflux inhibition and synergism. Potent whole-cell efflux inhibitors and synergistic compounds were identified, suggesting potential development as adjuncts to existing anti-tuberculosis chemotherapy./
| Type: | Article |
|---|---|
| Title: | C-1 Substituted isoquinolines potentiate the antimycobacterial activity of rifampicin and ethambutol |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/frabi.2023.1095013 |
| Publisher version: | https://doi.org/10.3389/frabi.2023.1095013 |
| Language: | English |
| Additional information: | © 2023 Martin, Lamming, Maitra, Mortazavi, Roddan, Ward, Bhakta and Hailes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | tuberculosis, mycobacteria, antimicrobial resistance, isoquinolines, synergism, efflux pump inhibition, antibiotic |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10169975 |
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