Dolphin, AC;
(2023)
Distinct pools of synaptic vesicles are released by different calcium channels.
Cell Calcium
, 112
, Article 102729. 10.1016/j.ceca.2023.102729.
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Abstract
Mueller et al. [1] uncover distinct roles for CaV1 and CaV2 channels in neurotransmitter release at the C. elegans neuromuscular junction. Although nanodomain coupling occurs via clustered CaV2 channels, evidence is also presented that release of a separate vesicular pool is mediated by more peripheral, dispersed CaV1 channels, requiring obligatory coupling with RYR to amplify the Ca2+ signal.
| Type: | Article |
|---|---|
| Title: | Distinct pools of synaptic vesicles are released by different calcium channels |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ceca.2023.102729 |
| Publisher version: | https://doi.org/10.1016/j.ceca.2023.102729 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | C. elegans, Calcium channel, Endoplasmic reticulum, Ryanodine receptor, Synaptic machinery, Synaptic vesicle, Animals, Calcium Channels, Synaptic Vesicles, Caenorhabditis elegans, Synaptic Transmission, Calcium, Ryanodine Receptor Calcium Release Channel |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Neuro, Physiology and Pharmacology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10170111 |
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