Spears, Richard J;
Chudasama, Vijay;
(2023)
Recent advances in N- and C-terminus cysteine protein bioconjugation.
Current Opinion in Chemical Biology
, 75
, Article 102306. 10.1016/j.cbpa.2023.102306.
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Abstract
Advances in the site-specific chemical modification of proteins, also referred to as protein bioconjugation, have proved instrumental in revolutionary approaches to designing new protein-based therapeutics. Of the sites available for protein modification, cysteine residues or the termini of proteins have proved especially popular owing to their favorable properties for site-specific modification. Strategies that, therefore, specifically target cysteine at the termini offer a combination of these favorable properties of cysteine and termini bioconjugation. In this review, we discuss these strategies with a particular focus on those reported recently and provide our opinion on the future direction of the field.
| Type: | Article |
|---|---|
| Title: | Recent advances in N- and C-terminus cysteine protein bioconjugation |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.cbpa.2023.102306 |
| Publisher version: | https://doi.org/10.1016/j.cbpa.2023.102306 |
| Language: | English |
| Additional information: | © 2023 The Author(s). Published by Elsevier Ltd. under a Creative Commons license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | C-terminal modification, Cysteine conjugation, N-terminal modification, Peptide modification, Protein modification, Termini modification |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10171067 |
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