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Ocular Inflammatory Events Following COVID-19 Vaccination in the Paediatric Population: A Multinational Case Series

Testi, Ilaria; Brandão-de-Resende, Camilo; De-La-Torre, Alejandra; Concha-Del-Rio, Luz Elena; Cheja-Kalb, Rashel; Mahendradas, Padmamalini; Habot-Wilner, Zohar; ... Solebo, Ameenat Lola; + view all (2023) Ocular Inflammatory Events Following COVID-19 Vaccination in the Paediatric Population: A Multinational Case Series. Ocular Immunology and Inflammation 10.1080/09273948.2023.2220782. (In press). Green open access

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Abstract

BACKGROUND: Ocular inflammatory events following COVID-19 vaccination have been reported in the adult population. METHODS: Multinational case series of patients under the age of 18 diagnosed with ocular inflammatory events within 28 days of COVID-19 vaccination. RESULTS: Twenty individuals were included. The most common event was anterior uveitis (n = 8, 40.0%), followed by intermediate uveitis (7 patients, 35%), panuveitis (4 patients, 20%), and posterior uveitis (1 patient, 5%). The event was noticed in the first week after vaccination in 11 patients (55.0%). Twelve patients (60.0%) had a previous history of intraocular inflammatory event. Patients were managed with topical corticosteroids (n = 19, 95.0%), oral corticosteroids (n = 10, 50.0%), or increased dose of immunosuppressive treatment (n = 6, 30.0%). Thirteen patients (65.0%) had a complete resolution of the ocular event without complications. All patients had a final visual acuity unaffected or less than three lines of loss. CONCLUSION: Ocular inflammatory events may happen in the paediatric population following COVID-19 vaccination. Most events were successfully treated, and all showed a good visual outcome.

Type: Article
Title: Ocular Inflammatory Events Following COVID-19 Vaccination in the Paediatric Population: A Multinational Case Series
Open access status: An open access version is available from UCL Discovery
DOI: 10.1080/09273948.2023.2220782
Publisher version: https://doi.org/10.1080/09273948.2023.2220782
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Paediatric; Uveitis; Ocular inflammation; Coronavirus; COVID-19; SARS-CoV2; Vaccination
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10172129
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