Dempsey, Seán D;
Ryan, Ailbhe A;
Smyth, Megan;
Moody, Thomas S;
Wharry, Scott;
Fahey, Karen;
Beale, Andrew M;
... Thompson, Jillian M; + view all
(2023)
Continuous-flow transfer hydrogenation of benzonitrile using formate as a safe and sustainable source of hydrogen.
Reaction Chemistry and Engineering
, 7
(8)
pp. 1559-1564.
10.1039/d3re00195d.
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Abstract
The continuous catalytic transfer hydrogenation of benzonitrile to benzylamine is demonstrated using a palladium on carbon catalyst with triethylammonium formate as reducing agent. Solvent choice was critical in overcoming rapid catalyst deactivation. A 15-fold increase in catalyst productivity was observed in flow compared to batch, which was achieved using an ethanol–water solvent in combination with intermittent catalyst regeneration by washing with water.
| Type: | Article |
|---|---|
| Title: | Continuous-flow transfer hydrogenation of benzonitrile using formate as a safe and sustainable source of hydrogen |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1039/d3re00195d |
| Publisher version: | https://doi.org/10.1039/D3RE00195D |
| Language: | English |
| Additional information: | © The Author(s). This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/3.0/ |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10172606 |
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