Hauser, Jakob A;
Burden, Samuel J;
Karunakaran, Ajanthiha;
Muthurangu, Vivek;
Taylor, Andrew M;
Jones, Alexander;
(2023)
Whole-Body Magnetic Resonance Imaging Assessment of the Contributions of Adipose and Nonadipose Tissues to Cardiovascular Remodeling in Adolescents.
Journal of the American Heart Association Cardiovascular and Cerebrovascular Disease
, Article e030221. 10.1161/JAHA.123.030221.
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Abstract
BACKGROUND: Greater body mass index is associated with cardiovascular remodeling in adolescents. However, body mass index cannot differentiate between adipose and nonadipose tissues. We examined how visceral and subcutaneous adipose tissue are linked with markers of early cardiovascular remodeling, independently from nonadipose tissue. METHODS AND RESULTS: Whole‐body magnetic resonance imaging was done in 82 adolescents (39 overweight/obese; 36 female; median age, 16.3 [interquartile range, 14.4–18.1] years) to measure body composition and cardiovascular remodeling markers. Left ventricular diastolic function was assessed by echocardiography. Waist, waist:height ratio, and body mass index z scores were calculated. Residualized nonadipose tissue, subcutaneous adipose tissue, and visceral adipose tissue variables, uncorrelated with each other, were constructed using partial regression modeling to allow comparison of their individual contributions in a 3‐compartment body composition model. Cardiovascular variables mostly related to nonadipose rather than adipose tissue. Nonadipose tissue was correlated positively with left ventricular mass (r=0.81), end‐diastolic volume (r=0.70), stroke volume (r=0.64), left ventricular mass:end‐diastolic volume (r=0.37), and systolic blood pressure (r=0.35), and negatively with heart rate (r=−0.33) (all P<0.01). Subcutaneous adipose tissue was associated with worse left ventricular diastolic function (r=−0.42 to −0.48, P=0.0007–0.02) and higher heart rates (r=0.34, P=0.007) but linked with better systemic vascular resistance (r=−0.35, P=0.006). There were no significant relationships with visceral adipose tissue and no associations of any compartment with pulse wave velocity. CONCLUSIONS: Simple anthropometry does not reflect independent effects of nonadipose tissue and subcutaneous adipose tissue on the adolescent cardiovascular system. This could result in normal cardiovascular adaptations to growth being misinterpreted as pathological sequelae of excess adiposity in studies reliant on such measures.
| Type: | Article |
|---|---|
| Title: | Whole-Body Magnetic Resonance Imaging Assessment of the Contributions of Adipose and Nonadipose Tissues to Cardiovascular Remodeling in Adolescents |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1161/JAHA.123.030221 |
| Publisher version: | https://doi.org/10.1161/JAHA.123.030221 |
| Language: | English |
| Additional information: | © 2023 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| Keywords: | Anthropometry, cardiovascular system, heart, obesity, pediatric |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Childrens Cardiovascular Disease |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10174199 |
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