Jaslan, Dawid;
Ferro, Irene Flavia;
Kudrina, Veronika;
Yuan, Yu;
Patel, Sandip;
Grimm, Christian;
(2023)
PI(3,5)P2 and NAADP: Team players or lone warriors?-New insights into TPC activation modes.
Cell Calcium
, 109
, Article 102675. 10.1016/j.ceca.2022.102675.
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Abstract
NAADP (nicotinic acid adenine dinucleotide phosphate) is a second messenger, releasing Ca2+ from acidic calcium stores such as endosomes and lysosomes. PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) is a phospho-inositide, residing on endolysosomal membranes and likewise releasing Ca2+ from endosomes and lysosomes. Both compounds have been shown to activate endolysosomal two-pore channels (TPCs) in mammalian cells. However, their effects on ion permeability as demonstrated specifically for TPC2 differ. While PI(3,5)P2 elicits predominantly Na+-selective currents, NAADP increases the Ca2+ permeability of the channel. What happens when both compounds are applied simultaneously was unclear until recently
| Type: | Article |
|---|---|
| Title: | PI(3,5)P2 and NAADP: Team players or lone warriors?-New insights into TPC activation modes |
| Location: | Netherlands |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ceca.2022.102675 |
| Publisher version: | https://doi.org/10.1016/j.ceca.2022.102675 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | 2-PORE CHANNELS, 5)P 2, CA2+, CALCIUM, CD38, Cell Biology, CHANNEL TPC1, Endosome, HOMEOSTASIS, IDENTIFICATION, INHIBITION, Life Sciences & Biomedicine, Lysosome, NAADP, PI(3, ROLES, Science & Technology, TPC1, TPC2, VOLTAGE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10175145 |
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