Mitchell, Arthur;
Benton, David;
Moss, Guy;
Dua, Vivek;
(2023)
Modelling the role of ion transport in controlling airway surface liquid.
Presented at: BIOREME researcher meetup, Warwick, UK.
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Abstract
ATP and protease activity in the airway surface liquid (ASL), are thought to control ASL depth. Many experiments have examined this control system by measuring absorption rates when excess fluid is added to the ASL. However, these experiments often use saline solutions that are not well matched to the ASL ion composition. We have developed a simple mathematical model of ion transport (Figure 1) and simulated the impact of changing ion composition alone without any ASL regulatory pathways.
| Type: | Poster |
|---|---|
| Title: | Modelling the role of ion transport in controlling airway surface liquid |
| Event: | BIOREME researcher meetup |
| Location: | Warwick, UK |
| Dates: | 13 January 2023 |
| Open access status: | An open access version is available from UCL Discovery |
| Publisher version: | https://www.bioreme.net/ |
| Language: | English |
| Keywords: | Cystic Fibrosis, Mathematical modelling |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10175433 |
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