Ferreira, Isabella ATM;
Lee, Colin YC;
Foster, William S;
Abdullahi, Adam;
Dratva, Lisa M;
Tuong, Zewen Kelvin;
Stewart, Benjamin J;
... Gupta, Ravindra K; + view all
(2023)
Atypical B cells and impaired SARS-CoV-2 neutralization following heterologous vaccination in the elderly.
Cell Reports
, 42
(8)
, Article 112991. 10.1016/j.celrep.2023.112991.
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Abstract
Suboptimal responses to a primary vaccination course have been reported in the elderly, but there is little information regarding the impact of age on responses to booster third doses. Here, we show that individuals 70 years or older (median age 73, range 70-75) who received a primary two-dose schedule with AZD1222 and booster third dose with mRNA vaccine achieve significantly lower neutralizing antibody responses against SARS-CoV-2 spike pseudotyped virus compared with those younger than 70 (median age 66, range 54-69) at 1 month post booster. Impaired neutralization potency and breadth post third dose in the elderly is associated with circulating "atypical" spike-specific B cells expressing CD11c and FCRL5. However, when considering individuals who received three doses of mRNA vaccine, we did not observe differences in neutralization or enrichment in atypical B cells. This work highlights the finding that AdV and mRNA COVID-19 vaccine formats differentially instruct the memory B cell response.
| Type: | Article |
|---|---|
| Title: | Atypical B cells and impaired SARS-CoV-2 neutralization following heterologous vaccination in the elderly |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.celrep.2023.112991 |
| Publisher version: | https://doi.org/10.1016/j.celrep.2023.112991 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | AZD1222, BNT162b2, CP: Immunology, SARS-CoV-2, elderly |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10175577 |
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