Konstantinidis, MK;
Ioannidis, A;
Vassiliu, P;
Arkadopoulos, N;
Papanikolaou, IS;
Stavridis, K;
Gallo, G;
... Konstantinidis, K; + view all
(2023)
Preoperative tumor marking with indocyanine green (ICG) prior to minimally invasive colorectal cancer: a systematic review of current literature.
Frontiers in Surgery
, 10
, Article 1258343. 10.3389/fsurg.2023.1258343.
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Abstract
AIMS: To describe the currently available evidence regarding the efficacy and safety of preoperative tumor marking using indocyanine green (ICG) prior to laparoscopic or robotic colorectal resections. METHODS: A systematic search for relevant studies was conducted using the following databases: Embase (OVID), MEDLINE® (OVID), APA PsycInfo (OVID), Global Health (OVID) and HMIC Health Management Information Consortium (OVID) through June 2022 reported according to PRISMA 2020 guidelines. Primary outcome was the detection rate of the tumor sites preoperatively marked with ICG. Secondary outcomes were timing of ICG injection in days prior to the operation and technique-related complications. RESULTS: Eight single center studies, published between 2008 and 2022, were identified yielding a total of 1,061 patients, of whom 696 were preoperatively tattooed with ICG. Injection dosage of diluted ICG ranged from 0.1–1.5 ml. Four studies used the saline test injection method prior to ICG injection. When the marking was placed within one week, the visualization rate was 650/668 (97%), whereas when it was longer than one week, the detection rate was 8/56 (14%). No severe complications were reported. CONCLUSION: Preoperative tumor marking using ICG prior to minimally invasive colorectal resections is safe and effective, allowing intraoperative tumor site location when performed up to a week prior to surgery without disturbing the surgical view in potential mild complications.
| Type: | Article |
|---|---|
| Title: | Preoperative tumor marking with indocyanine green (ICG) prior to minimally invasive colorectal cancer: a systematic review of current literature |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3389/fsurg.2023.1258343 |
| Publisher version: | https://doi.org/10.3389/fsurg.2023.1258343 |
| Language: | English |
| Additional information: | © 2023 Konstantinidis, Ioannidis, Vassiliu, Arkadopoulos, Papanikolaou, Stavridis, Gallo, Karagiannis, Chand, Wexner and Konstantinidis. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| Keywords: | Fluorescence imaging, indocyanine green, colorectal surgery, colorectal cancer, colorectal tumor, preoperative tumor marking, preoperative tattoo |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Targeted Intervention |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10176346 |
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