Sahota, Virender K;
Stone, Aelfwin;
Woodling, Nathaniel S;
Spiers, Jereme G;
Steinert, Joern R;
Partridge, Linda;
Augustin, Hrvoje;
(2023)
Plum modulates Myoglianin and regulates synaptic function in D. melanogaster.
Open Biology
, 13
(9)
, Article 230171. 10.1098/rsob.230171.
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Abstract
Alterations in the neuromuscular system underlie several neuromuscular diseases and play critical roles in the development of sarcopenia, the age-related loss of muscle mass and function. Mammalian Myostatin (MST) and GDF11, members of the TGF-β superfamily of growth factors, are powerful regulators of muscle size in both model organisms and humans. Myoglianin (MYO), the Drosophila homologue of MST and GDF11, is a strong inhibitor of synaptic function and structure at the neuromuscular junction in flies. Here, we identified Plum, a transmembrane cell surface protein, as a modulator of MYO function in the larval neuromuscular system. Reduction of Plum in the larval body-wall muscles abolishes the previously demonstrated positive effect of attenuated MYO signalling on both muscle size and neuromuscular junction structure and function. In addition, downregulation of Plum on its own results in decreased synaptic strength and body weight, classifying Plum as a (novel) regulator of neuromuscular function and body (muscle) size. These findings offer new insights into possible regulatory mechanisms behind ageing- and disease-related neuromuscular dysfunctions in humans and identify potential targets for therapeutic interventions.
| Type: | Article |
|---|---|
| Title: | Plum modulates Myoglianin and regulates synaptic function in D. melanogaster |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1098/rsob.230171 |
| Publisher version: | https://doi.org/10.1098/rsob.230171 |
| Language: | English |
| Additional information: | © 2023 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
| Keywords: | Drosophila melanogaster, myoglianin, neuromuscular junction, plum, synapse, Animals, Humans, Aging, Bone Morphogenetic Proteins, Down-Regulation, Drosophila, Drosophila melanogaster, Growth Differentiation Factors, Larva, Mammals, Prunus domestica |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10177237 |
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