Yacoub, Magdi H;
Tseng, Yuan-Tsan;
Kluin, Jolanda;
Vis, Annemijn;
Stock, Ulrich;
Smail, Hassiba;
Sarathchandra, Padmini;
... Latif, Najima; + view all
(2023)
Valvulogenesis of A Living, Innervated Pulmonary Root Induced By An Acellular Scaffold.
Communications Biology
, 6
, Article 1017. 10.1038/s42003-023-05383-z.
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Abstract
Heart valve disease is a major cause of mortality and morbidity worldwide with no effective medical therapy and no ideal valve substitute emulating the extremely sophisticated functions of a living heart valve. These functions influence survival and quality of life. This has stimulated extensive attempts at tissue engineering “living” heart valves. These attempts utilised combinations of allogeneic/ autologous cells and biological scaffolds with practical, regulatory, and ethical issues. In situ regeneration depends on scaffolds that attract, house and instruct cells and promote connective tissue formation. We describe a surgical, tissue-engineered, anatomically precise, novel off-the-shelf, acellular, synthetic scaffold inducing a rapid process of morphogenesis involving relevant cell types, extracellular matrix, regulatory elements including nerves and humoral components. This process relies on specific material characteristics, design and “morphodynamism”.
| Type: | Article |
|---|---|
| Title: | Valvulogenesis of A Living, Innervated Pulmonary Root Induced By An Acellular Scaffold |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/s42003-023-05383-z |
| Publisher version: | https://doi.org/10.1038/s42003-023-05383-z |
| Language: | English |
| Additional information: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
| Keywords: | Cardiac device therapy, Cardiovascular biology, Interventional cardiology |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10177396 |
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