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The providential randomisation of genotypes

Pingault, JB; Fearon, P; Viding, E; Davies, N; Munafò, MR; Davey Smith, G; (2023) The providential randomisation of genotypes. Behavioral and Brain Sciences , 46 , Article e197. 10.1017/S0140525X2200214X. Green open access

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Abstract

When building causal knowledge in behavioural genetics, the natural randomisation of genotypes at conception (approximately analogous to the artificial randomisation occurring in randomised controlled trials) facilitates the discovery of genetic causes. More importantly, the randomisation of genetic material within families also enables a better identification of (environmental) risk factors and aetiological pathways to diseases and behaviours.

Type: Article
Title: The providential randomisation of genotypes
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S0140525X2200214X
Publisher version: https://doi.org/10.1017/S0140525X2200214X
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Humans, Genotype, Knowledge
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Clinical, Edu and Hlth Psychology
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10177698
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