Li, Z;
Chen, D;
Li, Z;
Fan, H;
Guo, L;
Sui, B;
Ventikos, Y;
(2023)
A computational study of fluid transport characteristics in the brain parenchyma of dementia subtypes.
Journal of Biomechanics
, 159
, Article 111803. 10.1016/j.jbiomech.2023.111803.
(In press).
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Abstract
The cerebral environment is a complex system consisting of parenchymal tissue and multiple fluids. Dementia is a common class of neurodegenerative diseases, caused by structural damages and functional deficits in the cerebral environment. In order to better understand the pathology of dementia from a cerebral fluid transport angle and provide clearer evidence that could help differentiate between dementia subtypes, such as Alzheimer's disease and vascular dementia, we conducted fluid–structure interaction modelling of the brain using a multiple-network poroelasticity model, which considers both neuropathological and cerebrovascular factors. The parenchyma was further subdivided and labelled into parcellations to obtain more localised and detailed data. The numerical results were converted to computed functional images by an in-house workflow. Different cerebral blood flow (CBF) and cerebrospinal fluid (CSF) clearance abnormalities were identified in the modelling results, when comparing Alzheimer's disease and vascular dementia. This paper presents our preliminary results as a proof of concept for a novel clinical diagnostic tool, and paves the way for a larger clinical study.
| Type: | Article |
|---|---|
| Title: | A computational study of fluid transport characteristics in the brain parenchyma of dementia subtypes |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.jbiomech.2023.111803 |
| Publisher version: | https://doi.org/10.1016/j.jbiomech.2023.111803 |
| Language: | English |
| Additional information: | © 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Alzheimer’s disease, Vascular dementia, Poroelasticity, CSF, Blood perfusion |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10177842 |
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