Zinab, Beakal;
Ali, Rahma;
Megersa, Bikila S;
Belachew, Tefera;
Kedir, Elias;
Girma, Tsinuel;
Abdisa, Alemseged;
... Yilma, Daniel; + view all
(2023)
Association of linear growth velocities between 0 and 6 years with kidney function and size at 10 years: a birth cohort study in Ethiopia.
American Journal of Clinical Nutrition
10.1016/j.ajcnut.2023.09.014.
(In press).
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Abstract
BACKGROUND: The risk of non-communicable diseases accrues from fetal life, with early childhood growth having an important role for the risk of adult disease. There is a need to understand how early life growth relates to kidney function and size. OBJECTIVES: This study aimed to assess the association of linear growth velocities among children between 0 and 6 years with kidney function and size among children aged 10 years. METHODS: The Ethiopian Anthropometric and Body Composition (iABC) birth cohort recruited infants born at term to mothers living in Jimma, with a birth weight of ≥1500 grams, and without congenital malformations. Participants were followed up with 13 measurements between birth and 6 years of age. The latest follow-up was at ages 7-12 years with measurement of serum cystatin C as a marker of kidney function, and ultrasound assessment of kidney dimensions. Kidney volume was computed using an ellipsoid formula. Linear spline multi-level modelling was used to compute linear growth velocities between 0-6 years. Multiple linear regression modelling was used to examine the associations of linear growth velocities in selected age periods with cystatin C and kidney size. RESULTS: Data were captured from 355 children, at a mean age of 10 (range 7-12) years. The linear growth velocity was high between 0-3 months and then decreased with age. There was no evidence of an association of growth velocity up to 24 months with cystatin C at 10 years. Between 24-48 and 48-76 months, serum cystatin C was higher by 2.3% (95% CI 0.6, 4.2) and 2.1 % (95% CI 0.3, 4.0) for one SD higher linear growth velocity, respectively. We found a positive association between linear growth velocities at all intervals between 0-6 years and kidney volume. CONCLUSION: Greater growth between 0-6 years of development was positively associated with kidney size and greater growth velocity after 2 years was associated with higher serum cystatin C level.
| Type: | Article |
|---|---|
| Title: | Association of linear growth velocities between 0 and 6 years with kidney function and size at 10 years: a birth cohort study in Ethiopia |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ajcnut.2023.09.014 |
| Publisher version: | https://doi.org/10.1016/j.ajcnut.2023.09.014 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| Keywords: | cohort study, Ethiopia, Kidney function, Kidney size, linear growth velocities |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10178337 |
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