Gregory, Holly N;
Guillemot-Legris, Owein;
Crouch, Daisy;
Williams, Gareth;
Phillips, James B;
(2023)
Electrospun aligned tacrolimus-loaded polycaprolactone biomaterials for peripheral nerve repair.
Regenerative Medicine
10.2217/rme-2023-0151.
(In press).
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Abstract
Background: Efficacious repair of peripheral nerve injury is an unmet clinical need. The implantation of biomaterials containing neurotrophic drugs at the injury site could promote nerve regeneration and improve outcomes for patients. Materials & methods: Random and aligned electrospun poly-ε-caprolactone scaffolds containing encapsulated tacrolimus were fabricated, and the gene expression profile of Schwann cells (SCs) cultured on the surface was elucidated. On aligned fibers, the morphology of SCs and primary rat neurons was investigated. Results: Both scaffold types exhibited sustained release of drug, and the gene expression of SCs was modulated by both nanofibrous topography and the presence of tacrolimus. Aligned fibers promoted the alignment of SCs and orientated outgrowth from neurons. Conclusion: Electrospun PCL scaffolds with tacrolimus hold promise for the repair of peripheral nerve injury.
| Type: | Article |
|---|---|
| Title: | Electrospun aligned tacrolimus-loaded polycaprolactone biomaterials for peripheral nerve repair |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.2217/rme-2023-0151 |
| Publisher version: | https://doi.org/10.2217/rme-2023-0151 |
| Language: | English |
| Additional information: | This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | alignment, electrospinning, nanofibers, nerve regeneration, neurons, PCL, Schwann cells, tacrolimus |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmacology |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10178874 |
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