Bahou, Calise;
Spears, Richard J;
Ramírez Rosales, Angela M;
Rochet, Léa NC;
Barber, Lydia J;
Stankevich, Ksenia S;
Miranda, Juliana F;
... Spicer, Christopher D; + view all
(2023)
Hydrogel Cross-Linking via Thiol-Reactive Pyridazinediones.
Biomacromolecules
10.1021/acs.biomac.3c00290.
(In press).
Preview |
PDF
bahou-et-al-2023-hydrogel-cross-linking-via-thiol-reactive-pyridazinediones.pdf - Published Version Download (4MB) | Preview |
Abstract
Thiol-reactive Michael acceptors are commonly used for the formation of chemically cross-linked hydrogels. In this paper, we address the drawbacks of many Michael acceptors by introducing pyridazinediones as new cross-linking agents. Through the use of pyridazinediones and their mono- or dibrominated analogues, we show that the mechanical strength, swelling ratio, and rate of gelation can all be controlled in a pH-sensitive manner. Moreover, we demonstrate that the degradation of pyridazinedione-gels can be induced by the addition of thiols, thus providing a route to responsive or dynamic gels, and that monobromo-pyridazinedione gels are able to support the proliferation of human cells. We anticipate that our results will provide a valuable and complementary addition to the existing toolkit of cross-linking agents, allowing researchers to tune and rationally design the properties of biomedical hydrogels.
| Type: | Article |
|---|---|
| Title: | Hydrogel Cross-Linking via Thiol-Reactive Pyridazinediones |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1021/acs.biomac.3c00290 |
| Publisher version: | https://doi.org/10.1021/acs.biomac.3c00290 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third-party material in this article are included in the Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| Keywords: | Gelation, Hydrogels, Nucleic acid structure, Palladium, Thiols |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10179081 |
Archive Staff Only
 |
View Item |
