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Hippocampal adaptations in Mild Cognitive Impairment patients are modulated by bilingual language experiences

Voits, T; Rothman, J; Calabria, M; Robson, H; Aguirre, N; Cattaneo, G; Costumero, V; ... Pliatsikas, C; + view all (2023) Hippocampal adaptations in Mild Cognitive Impairment patients are modulated by bilingual language experiences. Bilingualism pp. 1-11. 10.1017/S1366728923000354. (In press). Green open access

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Abstract

Bilingualism has been shown to contribute to increased resilience against cognitive aging. One of the key brain structures linked to memory and dementia symptom onset, the hippocampus, has been observed to adapt in response to bilingual experience - at least in healthy individuals. However, in the context of neurodegenerative pathology, it is yet unclear what role previous bilingual experience might have in terms of sustaining integrity of this structure or related behavioral correlates. The present study adds to the limited cohort of research on the effects of bilingualism on neurocognitive outcomes in Mild Cognitive Impairment (MCI) using structural brain data. We investigate whether bilingual language experience (operationalized as language entropy) results in graded neurocognitive adaptations within a cohort of bilinguals diagnosed with MCI. Results reveal a non-linear effect of bilingual language entropy on hippocampal volume, although they do not predict episodic memory performance, nor age of MCI diagnosis.

Type: Article
Title: Hippocampal adaptations in Mild Cognitive Impairment patients are modulated by bilingual language experiences
Open access status: An open access version is available from UCL Discovery
DOI: 10.1017/S1366728923000354
Publisher version: https://doi.org/10.1017/S1366728923000354
Language: English
Additional information: © The Author(s), 2023. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/).
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Div of Psychology and Lang Sciences > Language and Cognition
URI: https://discovery-pp.ucl.ac.uk/id/eprint/10179091
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