Boso, Daniele;
Carraro, Eugenia;
Maghin, Edoardo;
Todros, Silvia;
Dedja, Arben;
Giomo, Monica;
Elvassore, Nicola;
... Piccoli, Martina; + view all
(2021)
Porcine Decellularized Diaphragm Hydrogel: A New Option for Skeletal Muscle Malformations.
Biomedicines
, 9
(7)
, Article 709. 10.3390/biomedicines9070709.
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Abstract
Hydrogels are biomaterials that, thanks to their unique hydrophilic and biomimetic characteristics, are used to support cell growth and attachment and promote tissue regeneration. The use of decellularized extracellular matrix (dECM) from different tissues or organs significantly demonstrated to be far superior to other types of hydrogel since it recapitulates the native tissue’s ECM composition and bioactivity. Different muscle injuries and malformations require the application of patches or fillers to replenish the defect and boost tissue regeneration. Herein, we develop, produce, and characterize a porcine diaphragmatic dECM-derived hydrogel for diaphragmatic applications. We obtain a tissue-specific biomaterial able to mimic the complex structure of skeletal muscle ECM; we characterize hydrogel properties in terms of biomechanical properties, biocompatibility, and adaptability for in vivo applications. Lastly, we demonstrate that dECM-derived hydrogel obtained from porcine diaphragms can represent a useful biological product for diaphragmatic muscle defect repair when used as relevant acellular stand-alone patch.
| Type: | Article |
|---|---|
| Title: | Porcine Decellularized Diaphragm Hydrogel: A New Option for Skeletal Muscle Malformations |
| Location: | Switzerland |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/biomedicines9070709 |
| Publisher version: | https://doi.org/10.3390/biomedicines9070709 |
| Language: | English |
| Additional information: | © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Medicine, Research & Experimental, Pharmacology & Pharmacy, Research & Experimental Medicine, tissue engineering, skeletal muscle, extracellular matrix, hydrogel, diaphragmatic hernia, SMALL-INTESTINAL SUBMUCOSA, EXTRACELLULAR-MATRIX, HERNIA REPAIR, CROSS-LINKING, PROSTHETIC PATCHES, SATELLITE CELLS, IN-VITRO, DIFFERENTIATION, COLLAGEN, MICROARCHITECTURE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10179122 |
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