Westbrook, Elizabeth R;
Ford, Hugh Z;
Antolović, Vlatka;
Chubb, Jonathan R;
(2023)
Clearing the slate: RNA turnover to enable cell state switching?
Development
, 150
(19)
, Article dev202084. 10.1242/dev.202084.
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Abstract
The distribution of mRNA in tissue is determined by the balance between transcription and decay. Understanding the control of RNA decay during development has been somewhat neglected compared with transcriptional control. Here, we explore the potential for mRNA decay to trigger rapid cell state transitions during development, comparing a bistable switch model of cell state conversion with experimental evidence from different developmental systems. We also consider another potential role for large-scale RNA decay that has emerged from studies of stress-induced cell state transitions, in which removal of mRNA unblocks the translation machinery to prioritise the synthesis of proteins that establish the new cell state.
| Type: | Article |
|---|---|
| Title: | Clearing the slate: RNA turnover to enable cell state switching? |
| Location: | England |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1242/dev.202084 |
| Publisher version: | https://doi.org/10.1242/dev.202084 |
| Language: | English |
| Additional information: | © 2023 Published by The Company of Biologists Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). |
| Keywords: | Cell state transition, RNA decay, Ribosome competition |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Lab for Molecular Cell Bio MRC-UCL |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10179231 |
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