Dziemidowicz, Karolina;
Kellaway, Simon C;
Guillemot-Legris, Owein;
Matar, Omar;
Trindade, Rita Pereira;
Roberton, Victoria H;
Rayner, Melissa LD;
... Phillips, James B; + view all
(2023)
Development of ibuprofen-loaded electrospun materials suitable for surgical implantation in peripheral nerve injury.
Biomaterials Advances
, 154
, Article 213623. 10.1016/j.bioadv.2023.213623.
(In press).
Preview |
Text
1-s2.0-S2772950823003461-main.pdf - Published Version Download (4MB) | Preview |
Abstract
The development of nerve wraps for use in the repair of peripheral nerves has shown promise over recent years. A pharmacological effect to improve regeneration may be achieved by loading such materials with therapeutic agents, for example ibuprofen, a non-steroidal anti-inflammatory drug with neuroregenerative properties. In this study, four commercially available polymers (polylactic acid (PLA), polycaprolactone (PCL) and two co-polymers containing different ratios of PLA to PCL) were used to fabricate ibuprofen-loaded nerve wraps using blend electrospinning. In vitro surgical handling experiments identified a formulation containing a PLA/PCL 70/30 molar ratio co-polymer as the most suitable for in vivo implantation. In a rat model, ibuprofen released from electrospun materials significantly improved the rate of axonal growth and sensory recovery over a 21-day recovery period following a sciatic nerve crush. Furthermore, RT-qPCR analysis of nerve segments revealed that the anti-inflammatory and neurotrophic effects of ibuprofen may still be observed 21 days after implantation. This suggests that the formulation developed in this work could have potential to improve nerve regeneration in vivo.
| Type: | Article |
|---|---|
| Title: | Development of ibuprofen-loaded electrospun materials suitable for surgical implantation in peripheral nerve injury |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.bioadv.2023.213623 |
| Language: | English |
| Additional information: | © 2023 Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Electrospinning, Peripheral nerve injury, Implants, Polymer, Biomaterial |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery-pp.ucl.ac.uk/id/eprint/10179308 |
Archive Staff Only
 |
View Item |
